(68)Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study.
Identifieur interne : 001355 ( Main/Exploration ); précédent : 001354; suivant : 001356(68)Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study.
Auteurs : Wolfgang Peter Fendler [États-Unis] ; Jeremie Calais [États-Unis] ; Martin Allen-Auerbach [États-Unis] ; Christina Bluemel [Allemagne] ; Nina Eberhardt [Allemagne] ; Louise Emmett [Australie] ; Pawan Gupta [États-Unis] ; Markus Hartenbach [Autriche] ; Thomas A. Hope [États-Unis] ; Shozo Okamoto [Japon] ; Christian Helmut Pfob [Allemagne] ; Thorsten D. Pöppel [Allemagne] ; Christoph Rischpler [Allemagne] ; Sarah Schwarzenböck [Allemagne] ; Vanessa Stebner [Allemagne] ; Marcus Unterrainer [Allemagne] ; Helle D. Zacho [Danemark] ; Tobias Maurer [Allemagne] ; Christian Gratzke [Allemagne] ; Alexander Crispin [Allemagne] ; Johannes Czernin [États-Unis] ; Ken Herrmann [États-Unis] ; Matthias Eiber [États-Unis]Source :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 1535-5667 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Biais de l'observateur, Composés organométalliques, Humains, Interprétation d'image assistée par ordinateur, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par émission de positons couplée à la tomodensitométrie, Tumeurs de la prostate (imagerie diagnostique), Études prospectives.
- MESH :
- imagerie diagnostique : Tumeurs de la prostate.
- Adulte d'âge moyen, Biais de l'observateur, Composés organométalliques, Humains, Interprétation d'image assistée par ordinateur, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par émission de positons couplée à la tomodensitométrie, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- chemical : Organometallic Compounds.
- diagnostic imaging : Prostatic Neoplasms.
- Aged, Aged, 80 and over, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Observer Variation, Positron Emission Tomography Computed Tomography, Prospective Studies.
Abstract
The interobserver agreement for (68)Ga-PSMA-11 PET/CT study interpretations in patients with prostate cancer is unknown. Methods:(68)Ga-PSMA-11 PET/CT was performed in 50 patients with prostate cancer for biochemical recurrence (n = 25), primary diagnosis (n = 10), biochemical persistence after primary therapy (n = 5), or staging of known metastatic disease (n = 10). Images were reviewed by 16 observers who used a standardized approach for interpretation of local (T), nodal (N), bone (Mb), or visceral (Mc) involvement. Observers were classified as having a low (<30 prior (68)Ga-PSMA-11 PET/CT studies; n = 5), intermediate (30-300 studies; n = 5), or high level of experience (>300 studies; n = 6). Histopathology (n = 25, 50%), post-external-beam radiation therapy prostate-specific antigen response (n = 15, 30%), or follow-up PET/CT (n = 10, 20%) served as a standard of reference. Observer groups were compared by overall agreement (% patients matching the standard of reference) and Fleiss' κ with mean and corresponding 95% confidence interval (CI). Results: Agreement among all observers was substantial for T (κ = 0.62; 95% CI, 0.59-0.64) and N (κ = 0.74; 95% CI, 0.71-0.76) staging and almost perfect for Mb (κ = 0.88; 95% CI, 0.86-0.91) staging. Level of experience positively correlated with agreement for T (κ = 0.73/0.66/0.50 for high/intermediate/low experience, respectively), N (κ = 0.80/0.76/0.64, respectively), and Mc staging (κ = 0.61/0.46/0.36, respectively). Interobserver agreement for Mb was almost perfect irrespective of prior experience (κ = 0.87/0.91/0.88, respectively). Observers with low experience, when compared with intermediate and high experience, demonstrated significantly lower median overall agreement (54% vs. 66% and 76%, P = 0.041) and specificity for T staging (73% vs. 88% and 93%, P = 0.032). Conclusion: The interpretation of (68)Ga-PSMA-11 PET/CT for prostate cancer staging is highly consistent among observers with high levels of experience, especially for nodal and bone assessments. Initial training on at least 30 patient cases is recommended to ensure acceptable performance.
DOI: 10.2967/jnumed.117.190827
PubMed: 28408531
Affiliations:
- Allemagne, Australie, Autriche, Danemark, Japon, États-Unis
- Bade-Wurtemberg, Bavière, Californie, District de Basse-Franconie, District de Haute-Bavière, District de Tübingen, Vienne (Autriche)
- Los Angeles, Munich, Ulm, Vienne (Autriche), Wurtzbourg
- Université Louis-et-Maximilien de Munich
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Le document en format XML
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Wales</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Pawan" sort="Gupta, Pawan" uniqKey="Gupta P" first="Pawan" last="Gupta">Pawan Gupta</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hartenbach, Markus" sort="Hartenbach, Markus" uniqKey="Hartenbach M" first="Markus" last="Hartenbach">Markus Hartenbach</name><affiliation wicri:level="3"><nlm:affiliation>Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country 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Hope</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Radiology and Biomedical Imaging, University of California, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Okamoto, Shozo" sort="Okamoto, Shozo" uniqKey="Okamoto S" first="Shozo" last="Okamoto">Shozo Okamoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Pfob, Christian Helmut" sort="Pfob, Christian Helmut" uniqKey="Pfob C" first="Christian Helmut" last="Pfob">Christian Helmut Pfob</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Poppel, Thorsten D" sort="Poppel, Thorsten D" uniqKey="Poppel T" first="Thorsten D" last="Pöppel">Thorsten D. Pöppel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Rischpler, Christoph" sort="Rischpler, Christoph" uniqKey="Rischpler C" first="Christoph" last="Rischpler">Christoph Rischpler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Schwarzenbock, Sarah" sort="Schwarzenbock, Sarah" uniqKey="Schwarzenbock S" first="Sarah" last="Schwarzenböck">Sarah Schwarzenböck</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Rostock University Medical Centre, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Stebner, Vanessa" sort="Stebner, Vanessa" uniqKey="Stebner V" first="Vanessa" last="Stebner">Vanessa Stebner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Unterrainer, Marcus" sort="Unterrainer, Marcus" uniqKey="Unterrainer M" first="Marcus" last="Unterrainer">Marcus Unterrainer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Zacho, Helle D" sort="Zacho, Helle D" uniqKey="Zacho H" first="Helle D" last="Zacho">Helle D. Zacho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Nuclear Medicine, Aalborg University Hospital, Aalborg</wicri:regionArea><wicri:noRegion>Aalborg</wicri:noRegion></affiliation></author><author><name sortKey="Maurer, Tobias" sort="Maurer, Tobias" uniqKey="Maurer T" first="Tobias" last="Maurer">Tobias Maurer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Urology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, Klinikum Rechts der Isar, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Gratzke, Christian" sort="Gratzke, Christian" uniqKey="Gratzke C" first="Christian" last="Gratzke">Christian Gratzke</name><affiliation wicri:level="4"><nlm:affiliation>Department of Urology, Ludwig-Maximilians-University of Munich, Munich, Germany; and.</nlm:affiliation><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Crispin, Alexander" sort="Crispin, Alexander" uniqKey="Crispin A" first="Alexander" last="Crispin">Alexander Crispin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich</wicri:regionArea><wicri:noRegion>Ludwig-Maximilians-University Munich</wicri:noRegion><wicri:noRegion>Ludwig-Maximilians-University Munich</wicri:noRegion><wicri:noRegion>Ludwig-Maximilians-University Munich</wicri:noRegion></affiliation></author><author><name sortKey="Czernin, Johannes" sort="Czernin, Johannes" uniqKey="Czernin J" first="Johannes" last="Czernin">Johannes Czernin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Herrmann, Ken" sort="Herrmann, Ken" uniqKey="Herrmann K" first="Ken" last="Herrmann">Ken Herrmann</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Eiber, Matthias" sort="Eiber, Matthias" uniqKey="Eiber M" first="Matthias" last="Eiber">Matthias Eiber</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28408531</idno><idno type="pmid">28408531</idno><idno type="doi">10.2967/jnumed.117.190827</idno><idno type="wicri:Area/PubMed/Corpus">000323</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000323</idno><idno type="wicri:Area/PubMed/Curation">000321</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000321</idno><idno type="wicri:Area/PubMed/Checkpoint">000321</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000321</idno><idno type="wicri:Area/Ncbi/Merge">004638</idno><idno type="wicri:Area/Ncbi/Curation">004638</idno><idno type="wicri:Area/Ncbi/Checkpoint">004638</idno><idno type="wicri:Area/Main/Merge">001350</idno><idno type="wicri:Area/Main/Curation">001355</idno><idno type="wicri:Area/Main/Exploration">001355</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">(68)Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study.</title><author><name sortKey="Fendler, Wolfgang Peter" sort="Fendler, Wolfgang Peter" uniqKey="Fendler W" first="Wolfgang Peter" last="Fendler">Wolfgang Peter Fendler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California wfendler@mednet.ucla.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Calais, Jeremie" sort="Calais, Jeremie" uniqKey="Calais J" first="Jeremie" last="Calais">Jeremie Calais</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Allen Auerbach, Martin" sort="Allen Auerbach, Martin" uniqKey="Allen Auerbach M" first="Martin" last="Allen-Auerbach">Martin Allen-Auerbach</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Bluemel, Christina" sort="Bluemel, Christina" uniqKey="Bluemel C" first="Christina" last="Bluemel">Christina Bluemel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Julius-Maximilians-University of Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Julius-Maximilians-University of Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Eberhardt, Nina" sort="Eberhardt, Nina" uniqKey="Eberhardt N" first="Nina" last="Eberhardt">Nina Eberhardt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Ulm University, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Ulm University, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Emmett, Louise" sort="Emmett, Louise" uniqKey="Emmett L" first="Louise" last="Emmett">Louise Emmett</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic Imaging, St. Vincent's Public Hospital, Sydney, Australia, and University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Diagnostic Imaging, St. Vincent's Public Hospital, Sydney, Australia, and University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Pawan" sort="Gupta, Pawan" uniqKey="Gupta P" first="Pawan" last="Gupta">Pawan Gupta</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hartenbach, Markus" sort="Hartenbach, Markus" uniqKey="Hartenbach M" first="Markus" last="Hartenbach">Markus Hartenbach</name><affiliation wicri:level="3"><nlm:affiliation>Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Hope, Thomas A" sort="Hope, Thomas A" uniqKey="Hope T" first="Thomas A" last="Hope">Thomas A. Hope</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Radiology and Biomedical Imaging, University of California, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Okamoto, Shozo" sort="Okamoto, Shozo" uniqKey="Okamoto S" first="Shozo" last="Okamoto">Shozo Okamoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Pfob, Christian Helmut" sort="Pfob, Christian Helmut" uniqKey="Pfob C" first="Christian Helmut" last="Pfob">Christian Helmut Pfob</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Poppel, Thorsten D" sort="Poppel, Thorsten D" uniqKey="Poppel T" first="Thorsten D" last="Pöppel">Thorsten D. Pöppel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Rischpler, Christoph" sort="Rischpler, Christoph" uniqKey="Rischpler C" first="Christoph" last="Rischpler">Christoph Rischpler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Schwarzenbock, Sarah" sort="Schwarzenbock, Sarah" uniqKey="Schwarzenbock S" first="Sarah" last="Schwarzenböck">Sarah Schwarzenböck</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Rostock University Medical Centre, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Stebner, Vanessa" sort="Stebner, Vanessa" uniqKey="Stebner V" first="Vanessa" last="Stebner">Vanessa Stebner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Unterrainer, Marcus" sort="Unterrainer, Marcus" uniqKey="Unterrainer M" first="Marcus" last="Unterrainer">Marcus Unterrainer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Zacho, Helle D" sort="Zacho, Helle D" uniqKey="Zacho H" first="Helle D" last="Zacho">Helle D. Zacho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Nuclear Medicine, Aalborg University Hospital, Aalborg</wicri:regionArea><wicri:noRegion>Aalborg</wicri:noRegion></affiliation></author><author><name sortKey="Maurer, Tobias" sort="Maurer, Tobias" uniqKey="Maurer T" first="Tobias" last="Maurer">Tobias Maurer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Urology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, Klinikum Rechts der Isar, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Gratzke, Christian" sort="Gratzke, Christian" uniqKey="Gratzke C" first="Christian" last="Gratzke">Christian Gratzke</name><affiliation wicri:level="4"><nlm:affiliation>Department of Urology, Ludwig-Maximilians-University of Munich, Munich, Germany; and.</nlm:affiliation><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Crispin, Alexander" sort="Crispin, Alexander" uniqKey="Crispin A" first="Alexander" last="Crispin">Alexander Crispin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich</wicri:regionArea><wicri:noRegion>Ludwig-Maximilians-University Munich</wicri:noRegion><wicri:noRegion>Ludwig-Maximilians-University Munich</wicri:noRegion><wicri:noRegion>Ludwig-Maximilians-University Munich</wicri:noRegion></affiliation></author><author><name sortKey="Czernin, Johannes" sort="Czernin, Johannes" uniqKey="Czernin J" first="Johannes" last="Czernin">Johannes Czernin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Herrmann, Ken" sort="Herrmann, Ken" uniqKey="Herrmann K" first="Ken" last="Herrmann">Ken Herrmann</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Eiber, Matthias" sort="Eiber, Matthias" uniqKey="Eiber M" first="Matthias" last="Eiber">Matthias Eiber</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of nuclear medicine : official publication, Society of Nuclear Medicine</title><idno type="eISSN">1535-5667</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Image Interpretation, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Observer Variation</term><term>Organometallic Compounds</term><term>Positron Emission Tomography Computed Tomography</term><term>Prospective Studies</term><term>Prostatic Neoplasms (diagnostic imaging)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Biais de l'observateur</term><term>Composés organométalliques</term><term>Humains</term><term>Interprétation d'image assistée par ordinateur</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tomographie par émission de positons couplée à la tomodensitométrie</term><term>Tumeurs de la prostate (imagerie diagnostique)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Image Interpretation, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Observer Variation</term><term>Positron Emission Tomography Computed Tomography</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Biais de l'observateur</term><term>Composés organométalliques</term><term>Humains</term><term>Interprétation d'image assistée par ordinateur</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tomographie par émission de positons couplée à la tomodensitométrie</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The interobserver agreement for (68)Ga-PSMA-11 PET/CT study interpretations in patients with prostate cancer is unknown. Methods:(68)Ga-PSMA-11 PET/CT was performed in 50 patients with prostate cancer for biochemical recurrence (n = 25), primary diagnosis (n = 10), biochemical persistence after primary therapy (n = 5), or staging of known metastatic disease (n = 10). Images were reviewed by 16 observers who used a standardized approach for interpretation of local (T), nodal (N), bone (Mb), or visceral (Mc) involvement. Observers were classified as having a low (<30 prior (68)Ga-PSMA-11 PET/CT studies; n = 5), intermediate (30-300 studies; n = 5), or high level of experience (>300 studies; n = 6). Histopathology (n = 25, 50%), post-external-beam radiation therapy prostate-specific antigen response (n = 15, 30%), or follow-up PET/CT (n = 10, 20%) served as a standard of reference. Observer groups were compared by overall agreement (% patients matching the standard of reference) and Fleiss' κ with mean and corresponding 95% confidence interval (CI). Results: Agreement among all observers was substantial for T (κ = 0.62; 95% CI, 0.59-0.64) and N (κ = 0.74; 95% CI, 0.71-0.76) staging and almost perfect for Mb (κ = 0.88; 95% CI, 0.86-0.91) staging. Level of experience positively correlated with agreement for T (κ = 0.73/0.66/0.50 for high/intermediate/low experience, respectively), N (κ = 0.80/0.76/0.64, respectively), and Mc staging (κ = 0.61/0.46/0.36, respectively). Interobserver agreement for Mb was almost perfect irrespective of prior experience (κ = 0.87/0.91/0.88, respectively). Observers with low experience, when compared with intermediate and high experience, demonstrated significantly lower median overall agreement (54% vs. 66% and 76%, P = 0.041) and specificity for T staging (73% vs. 88% and 93%, P = 0.032). Conclusion: The interpretation of (68)Ga-PSMA-11 PET/CT for prostate cancer staging is highly consistent among observers with high levels of experience, especially for nodal and bone assessments. Initial training on at least 30 patient cases is recommended to ensure acceptable performance.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Danemark</li><li>Japon</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Californie</li><li>District de Basse-Franconie</li><li>District de Haute-Bavière</li><li>District de Tübingen</li><li>Vienne (Autriche)</li></region><settlement><li>Los Angeles</li><li>Munich</li><li>Ulm</li><li>Vienne (Autriche)</li><li>Wurtzbourg</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Fendler, Wolfgang Peter" sort="Fendler, Wolfgang Peter" uniqKey="Fendler W" first="Wolfgang Peter" last="Fendler">Wolfgang Peter Fendler</name></region><name sortKey="Allen Auerbach, Martin" sort="Allen Auerbach, Martin" uniqKey="Allen Auerbach M" first="Martin" last="Allen-Auerbach">Martin Allen-Auerbach</name><name sortKey="Calais, Jeremie" sort="Calais, Jeremie" uniqKey="Calais J" first="Jeremie" last="Calais">Jeremie Calais</name><name sortKey="Czernin, Johannes" sort="Czernin, Johannes" uniqKey="Czernin J" first="Johannes" last="Czernin">Johannes Czernin</name><name sortKey="Eiber, Matthias" sort="Eiber, Matthias" uniqKey="Eiber M" first="Matthias" last="Eiber">Matthias Eiber</name><name sortKey="Gupta, Pawan" sort="Gupta, Pawan" uniqKey="Gupta P" first="Pawan" last="Gupta">Pawan Gupta</name><name sortKey="Herrmann, Ken" sort="Herrmann, Ken" uniqKey="Herrmann K" first="Ken" last="Herrmann">Ken Herrmann</name><name sortKey="Hope, Thomas A" sort="Hope, Thomas A" uniqKey="Hope T" first="Thomas A" last="Hope">Thomas A. Hope</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Bluemel, Christina" sort="Bluemel, Christina" uniqKey="Bluemel C" first="Christina" last="Bluemel">Christina Bluemel</name></region><name sortKey="Crispin, Alexander" sort="Crispin, Alexander" uniqKey="Crispin A" first="Alexander" last="Crispin">Alexander Crispin</name><name sortKey="Eberhardt, Nina" sort="Eberhardt, Nina" uniqKey="Eberhardt N" first="Nina" last="Eberhardt">Nina Eberhardt</name><name sortKey="Gratzke, Christian" sort="Gratzke, Christian" uniqKey="Gratzke C" first="Christian" last="Gratzke">Christian Gratzke</name><name sortKey="Maurer, Tobias" sort="Maurer, Tobias" uniqKey="Maurer T" first="Tobias" last="Maurer">Tobias Maurer</name><name sortKey="Pfob, Christian Helmut" sort="Pfob, Christian Helmut" uniqKey="Pfob C" first="Christian Helmut" last="Pfob">Christian Helmut Pfob</name><name sortKey="Poppel, Thorsten D" sort="Poppel, Thorsten D" uniqKey="Poppel T" first="Thorsten D" last="Pöppel">Thorsten D. Pöppel</name><name sortKey="Rischpler, Christoph" sort="Rischpler, Christoph" uniqKey="Rischpler C" first="Christoph" last="Rischpler">Christoph Rischpler</name><name sortKey="Schwarzenbock, Sarah" sort="Schwarzenbock, Sarah" uniqKey="Schwarzenbock S" first="Sarah" last="Schwarzenböck">Sarah Schwarzenböck</name><name sortKey="Stebner, Vanessa" sort="Stebner, Vanessa" uniqKey="Stebner V" first="Vanessa" last="Stebner">Vanessa Stebner</name><name sortKey="Unterrainer, Marcus" sort="Unterrainer, Marcus" uniqKey="Unterrainer M" first="Marcus" last="Unterrainer">Marcus Unterrainer</name></country><country name="Australie"><noRegion><name sortKey="Emmett, Louise" sort="Emmett, Louise" uniqKey="Emmett L" first="Louise" last="Emmett">Louise Emmett</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Hartenbach, Markus" sort="Hartenbach, Markus" uniqKey="Hartenbach M" first="Markus" last="Hartenbach">Markus Hartenbach</name></region></country><country name="Japon"><noRegion><name sortKey="Okamoto, Shozo" sort="Okamoto, Shozo" uniqKey="Okamoto S" first="Shozo" last="Okamoto">Shozo Okamoto</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Zacho, Helle D" sort="Zacho, Helle D" uniqKey="Zacho H" first="Helle D" last="Zacho">Helle D. 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